HCID 67343263, compound → (2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide

HRID 1670031Notes

Reaction equation

HRID 1670031 reaction equation
C([N:11]1[CH2:15]C[C@H:13]([NH:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)[CH2:12]1)(OCC1C=CC=CC=1)=O.[C:23]([NH:30][C@H:31]([CH2:40][C:41]1[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=1)[C:32]([NH:34]N1CC(=O)C1)=[O:33])([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[C:23]([NH:30][C@H:31]([CH2:40][C:41]1[CH:46]=[CH:45][C:44]([Cl:47])=[CH:43][CH:42]=1)[C:32]([NH:34][N:11]1[CH2:12][CH:13]([NH:16][CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[CH2:15]1)=[O:33])([O:25][C:26]([CH3:28])([CH3:29])[CH3:27])=[O:24]

Participants

3

Reactant 2

HCID 67343263HCID 67343263, compoundHCID 67345314(2R)-2-(BOC)amino-N-(3-oxo-azetidine-1-yl)-3-(4-chlorophenyl)propionamide2×

Product 1

HCID 67342965(2R)-2-(BOC)amino-N-[3-(cyclohexylamino)azetidine-1-yl]-3-(4-chlorophenyl)propionamide

Procedure

The title compound was prepared following the procedure described in Intermediate 2 using (2R)-2-(BOC-amino)-N-(3-oxo-azetidine-1-yl)-3-(4-chlorophenyl)propionamide prepared in Intermediate 201 and cyclohexylamines.

Sources & evidence

ORD record
ord-6aa44fc5f4354c07911b267edd1a7c4a
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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