3-Oxo-azetidine-1-carboxylic acid tert-butyl ester → HCID 67344487, compound

HRID 1670038Notes

Reaction equation

HRID 1670038 reaction equation
OC(C(F)(F)F)=O.[NH2:8][C@H:9]([CH2:30][C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)[C:10]([NH:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH2:14]1)=[O:11].[C:38]([N:45]1[CH2:48][C:47](=O)[CH2:46]1)([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]>>[C:38]([N:45]1[CH2:46][CH:47]([NH:8][C@H:9]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)[C:10]([NH:12][N:13]2[CH2:17][CH2:16][C@H:15]([N:18]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[CH2:14]2)=[O:11])[CH2:48]1)([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]

Participants

3

Reactant 2

HCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl esterHCID 86612824HCID 86612824, compound

Product 1

HCID 67344487HCID 67344487, compound

Procedure

The title compound was prepared following the procedure described in Step A of Example 3 using (2R)-2-amino-N-{(3S)-3-[cyclohexyl(isobutyryl)amino]pyrrolidine-1-yl}-3-(4-chlorophenyl)propionamide TFA prepared in Example 1 and BOC-3-oxo-azetidine.

Sources & evidence

ORD record
ord-19abf32e06404362bd95ebd34160f8bc
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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