HCID 86761387, compound → HCID 67346608, compound

HRID 1670041Notes

Reaction equation

HRID 1670041 reaction equation
OC(C(F)(F)F)=O.[NH2:8][C@H:9]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=1)[C:10]([NH:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:19](=[O:24])[C@H:20]([CH3:23])[CH2:21][OH:22])[CH2:14]1)=[O:11]>CO>[ClH:38].[NH2:8][C@H:9]([CH2:31][C:32]1[CH:33]=[CH:34][C:35]([Cl:38])=[CH:36][CH:37]=1)[C:10]([NH:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:19](=[O:24])[C@H:20]([CH3:23])[CH2:21][OH:22])[CH2:14]1)=[O:11]

Participants

3

Reactant 1

HCID 86761387HCID 86761387, compound

Product 1

HCID 67346608HCID 67346608, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2R)-2-amino-N-{(3S)-3-[cyclohexyl((2R)-2-methyl-3-hydroxypropionyl)amino]pyrrolidine-1-yl}-3-(4-chlorophenyl)propionamide TFA prepared in the above Step C was dissolved in methanol, and passed though HCl-substituted ion exchange resin to give the title compound.

Sources & evidence

ORD record
ord-35ed6542556540a89cfe338705242b39
Source dataset
uspto-grants-2011_08
Patent number
US07989634B2

Reaction notes

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