Formaldehyde → HCID 67345562, compound

HRID 1670043Notes

Reaction equation

[C:1]([NH:8][CH2:9][CH2:10][NH:11][C@H:12]([CH2:33][C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=1)[C:13]([NH:15][N:16]1[CH2:20][CH2:19][C@H:18]([N:21]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[CH2:17]1)=[O:14])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:41]=O>>[CH3:41][CH:9]([NH:8][C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[CH2:10][NH:11][C@H:12]([CH2:33][C:34]1[CH:35]=[CH:36][C:37]([Cl:40])=[CH:38][CH:39]=1)[C:13]([NH:15][N:16]1[CH2:20][CH2:19][C@H:18]([N:21]([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[CH2:17]1)=[O:14]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 67346922HCID 67346922, compound

Product 1

HCID 67345562HCID 67345562, compound

Procedure

The title compound was prepared following the procedure described in Step A of Example 3 using (2R)-2-[2-(BOC)aminoethyl]amino-N-{(3S)-3-[cyclohexyl(isobutyryl)amino]pyrrolidine-1-yl}-3-(4-chlorophenyl)propionamide prepared in Step A of Example 360 and formaline.

Sources & evidence

ORD record: ord-d12980d02fa14150bb321a07bd431f39
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989634B2

Reaction notes

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