Methyl iodide → HCID 67344289, compound

HRID 1670044Notes

Reaction equation

[CH3:1][CH:2]([NH:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:3][NH:4][C@H:5]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=1)[C:6]([NH:8][N:9]1[CH2:13][CH2:12][C@H:11]([N:14]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17])[CH2:10]1)=[O:7].[CH3:42]I>>[CH3:1][CH:2]([N:34]([CH3:42])[C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH2:3][NH:4][C@H:5]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=1)[C:6]([NH:8][N:9]1[CH2:13][CH2:12][C@H:11]([N:14]([CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:15](=[O:19])[CH:16]([CH3:17])[CH3:18])[CH2:10]1)=[O:7]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 67345562HCID 67345562, compound

Product 1

HCID 67344289HCID 67344289, compound

Procedure

The title compound was prepared following the procedure described in Step A of Example 128 using (2R)-2-{methyl[2-(BOC)aminoethyl]}amino-N-{(3S)-3-[cyclohexyl(isobutyryl)amino]pyrrolidine-1-yl}-3-(4-chlorophenyl)propionamide prepared in the above Step A and methyliodide.

Sources & evidence

ORD record: ord-a6c01c0f018848b5a3135715212cd42e
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989634B2

Reaction notes

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