HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Benzyloxy-3'-fluoro-biphenyl-3-carboxylic Acid tert-butyl Ester → 3'-Fluoro-5-hydroxy-biphenyl-3-carboxylic Acid tert-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Benzyloxy-3'-fluoro-biphenyl-3-carboxylic Acid tert-butyl Ester | HCID 67338323 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3'-Fluoro-5-hydroxy-biphenyl-3-carboxylic Acid tert-butyl Ester | HCID 67339884 | 96% |
Reaction Steps
5-Benzyloxy-3′-fluoro-biphenyl-3-carboxylic acid tert-butyl ester (4.1 g) was dissolved in EtOH (50 mL) and hydrogenated in Parr apparatus over 10% Pd/C (410 mg) for 1 h. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to yield the title compound (3.0 g, 96% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989454B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-8a041e67498849819270c8d9ff68770c |
| Source note | uspto-grants-2011_08 |