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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1670086Generated: November 2, 2026

5-{6-[2-(2-Ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-3'-fluoro-biphenyl-3-carboxylic acid tert-butyl ester → HCID 67338077, compound

https://huagongshe.com/reaction/1670086

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-{6-[2-(2-Ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-3'-fluoro-biphenyl-3-carboxylic acid tert-butyl esterHCID 67338583—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
ProductHCID 67338077HCID 6733807791.9%

Reaction Steps

5-{6-[2-(2-Ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-3′-fluoro-biphenyl-3-carboxylic acid tert-butyl ester (7.0 g) was dissolved in a mixture of TFA and dichloromethane (1:1, 80 mL) and stirred at room temperature for 1 h. The solvents were removed under reduced pressure and the crude material was purified on a silica gel column using ethyl acetate and hexanes to yield the title compound (5.9 g, 90% yield).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989454B2
Source datasetuspto-grants-2011_08
ORD IDord-feb875750485446188cfa8897fdd4e3e
Source noteuspto-grants-2011_08