Tert-butyl 1,4-diazepane-1-carboxylate → HCID 42643885, compound
Reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:27]=[C:28]([C:40]3[CH:45]=[CH:44][CH:43]=[C:42]([F:46])[CH:41]=3)[CH:29]=[C:30](C(N3CCNCC3)=O)[CH:31]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2].C(OC(CCC1C(OCCCC(OCC)=O)=CC=CC=1CCCCCCOC1C=C(C(O)=O)C=C(C2C=CC=C(F)C=2)C=1)=O)C.C(O[C:97]([N:99]1[CH2:105][CH2:104][CH2:103][NH:102][CH2:101][CH2:100]1)=[O:98])(C)(C)C>>[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:27]=[C:28]([C:40]3[CH:45]=[CH:44][CH:43]=[C:42]([F:46])[CH:41]=3)[CH:29]=[C:30]([C:97]([N:99]3[CH2:105][CH2:104][CH2:103][NH:102][CH2:101][CH2:100]3)=[O:98])[CH:31]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2]Participants
4
Procedure
The title compound was prepared by the same method as 4-(2-(2-carboxy-ethyl)-3-{6-[3′-fluoro-5-(piperazine-1-carbonyl)-biphenyl-3-yloxy]-hexyl}-phenoxy)-butyric acid starting from 5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-3′-fluoro-biphenyl-3-carboxylic acid and [1,4]diazepane-1-carboxylic acid tert-butyl ester.
Sources & evidence
- ORD record
- ord-35c689859b6049e798347cb3263660d4
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07989454B2
Reaction notes
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