Sodium Hydroxide → 3-Bromo-5-hydroxybenzoic acid

Temperature

100 °C

To a solution of NaOH (12.2 g; 305.8 mmol) in 300 mL of water was added 3-bromo-5-iodo-benzoic acid (20 g, 61.2 mmol) and Cu2O (866 mg, 6.1 mmol). The reaction mixture was heated at 100° C. for 24 h. After complete consumption of the starting material, the reaction mixture was cooled to room temperature and filtered through Celite™. The filtrate was then acidified with 10% aq. HCl and extracted into ethyl acetate. The organic extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the title compound as a tan solid (12.3 g, 93% yield).

1. customAfter complete consumption of the starting material
2. temperaturethe reaction mixture was cooled to room temperature
3. filtrationfiltered through Celite™
4. extractionextracted into ethyl acetate
5. extractionThe organic extract
6. dry with materialwas dried over anhydrous sodium sulfate
7. concentrationconcentrated under reduced pressure

ORD record

ord-6f8a4781aeca4539ae7d434d61fad052

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07989454B2