3-{6-[2-(2-Ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic Acid → 3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-benzoic Acid

HRID 1670100Notes

Reaction equation

HRID 1670100 reaction equation
C(OC(CCC1C(OCCCC(OCC)=O)=CC=CC=1CCCCCCOC1C=C(C=C(C2C(C)=CSC=2)C=1)C(O)=O)=O)C.C([O:49][C:50](=[O:96])[C:51]1[CH:56]=[C:55]([O:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][C:64]2[CH:69]=[CH:68][CH:67]=[C:66]([O:70][CH2:71][CH2:72][CH2:73][C:74]([O:76][CH2:77][CH3:78])=[O:75])[C:65]=2[CH2:79][CH2:80][C:81]([O:83][CH2:84][CH3:85])=[O:82])[CH:54]=[C:53]([C:86]2[CH:95]=[CH:94][C:89]3[O:90][CH2:91][CH2:92][O:93][C:88]=3[CH:87]=2)[CH:52]=1)(C)(C)C>>[O:90]1[C:89]2[CH:94]=[CH:95][C:86]([C:53]3[CH:52]=[C:51]([CH:56]=[C:55]([O:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][C:64]4[CH:69]=[CH:68][CH:67]=[C:66]([O:70][CH2:71][CH2:72][CH2:73][C:74]([O:76][CH2:77][CH3:78])=[O:75])[C:65]=4[CH2:79][CH2:80][C:81]([O:83][CH2:84][CH3:85])=[O:82])[CH:54]=3)[C:50]([OH:96])=[O:49])=[CH:87][C:88]=2[O:93][CH2:92][CH2:91]1

Participants

3

Reactant 2

HCID 673382323-{6-[2-(2-Ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic AcidHCID 673388323-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-benzoic Acid tert-butyl Ester

Product 1

HCID 673380073-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-benzoic Acid

Procedure

The title compound was prepared by the same method as 3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-(4-methyl-thiophen-3-yl)-benzoic acid starting from 3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-benzoic acid tert-butyl ester.

Sources & evidence

ORD record
ord-82b296bedeec4cb082a4db492fca5168
Source dataset
uspto-grants-2011_08
Patent number
US07989454B2

Reaction notes

Loading…