Tert-butyl 1,4-diazepane-1-carboxylate → HCID 42643884, compound

HRID 1670116Notes

Reaction equation

HRID 1670116 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[C:30]([C:32]3[CH:36]=[CH:35][S:34][CH:33]=3)[CH:29]=[C:28]([C:37]([N:39]3[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]3)=[O:38])[CH:27]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2].[CH2:45](OC(CCC1C(OCCCC(OCC)=O)=CC=CC=1CCCCCCOC1C=C(C=C(C2C=CSC=2)C=1)C(O)=O)=O)C.C(OC(N1CCCNCC1)=O)(C)(C)C>>[C:1]([CH2:4][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:26]2[CH:31]=[C:30]([C:32]3[CH:36]=[CH:35][S:34][CH:33]=3)[CH:29]=[C:28]([C:37]([N:39]3[CH2:44][CH2:45][CH2:43][NH:42][CH2:41][CH2:40]3)=[O:38])[CH:27]=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 2756058Tert-butyl 1,4-diazepane-1-carboxylateHCID 67338878HCID 67338878, compoundHCID 67339611HCID 67339611, compound

Product 1

HCID 42643884HCID 42643884, compound

Procedure

The title compound was prepared by the same method as 4-(2-(2-carboxy-ethyl)-3-{6-[3-(piperazine-1-carbonyl)-5-thiophen-3-yl-phenoxy]-hexyl}-phenoxy)-butyric acid starting from 3-{6-[2-(2-ethoxycarbonyl-ethyl)-3-(3-ethoxycarbonyl-propoxy)-phenyl]-hexyloxy}-5-thiophen-3-yl-benzoic acid and [1,4]diazepane-1-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-aee6755ae97e42999efc5a4caec3b8f7
Source dataset
uspto-grants-2011_08
Patent number
US07989454B2

Reaction notes

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