4-(4-Chlorophenyl)piperidine → tert-butyl N-[[1-[4-[[4-(4-chlorophenyl)piperidine-1-carbonyl]amino]phenyl]pyrrolidin-3-yl]methyl]carbamate

HRID 167013Notes

Reaction equation

HRID 167013 reaction equation
[C:22](=[O:23])([c:24]1[nH:25][cH:26][cH:27][n:28]1)[c:29]1[nH:30][cH:31][cH:32][n:33]1.[Cl:34][c:35]1[cH:36][cH:37][c:38]([CH:41]2[CH2:42][CH2:43][NH:44][CH2:45][CH2:46]2)[cH:39][cH:40]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH:10]([CH2:13][NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:11][CH2:12]2)[cH:6][cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([N:8]2[CH2:9][CH:10]([CH2:13][NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:11][CH2:12]2)[cH:6][cH:7]1)[C:22](=[O:23])[N:44]1[CH2:43][CH2:42][CH:41]([c:38]2[cH:37][cH:36][c:35]([Cl:34])[cH:40][cH:39]2)[CH2:46][CH2:45]1

Participants

4

Reactant 3

HCID 12036134-(4-Chlorophenyl)piperidineHCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 57358980[1-(4-Amino-phenyl)-pyrrolidin-3-ylmethyl]-carbamic acid tert-butyl ester

Product 1

HCID 90753380tert-butyl N-[[1-[4-[[4-(4-chlorophenyl)piperidine-1-carbonyl]amino]phenyl]pyrrolidin-3-yl]methyl]carbamate

Sources & evidence

ORD record
ord-55ade658f3e244f0bba22eed79279127
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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