Sodium Hydroxide → 4-(2-(2-Carboxy-ethyl)-3-{6-[5-(3,3-difluoro-pyrrolidine-1-carbonyl)-biphenyl-3-yloxy]-hexyl}-phenoxy)-butyric acid

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Reaction Steps

The title compound was prepared by the same method as 4-{2-(2-carboxy-ethyl)-3-[6-(5-dimethylcarbamoyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid starting from 4-[3-{6-[5-(3,3-difluoro-pyrrolidine-1-carbonyl)-biphenyl-3-yloxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (70 mg, 0.101 mmol) and 1.0 N aqueous NaOH (1.01 mL) in EtOH (4 mL) to afford 4-(2-(2-carboxy-ethyl)-3-{6-[5-(3,3-difluoro-pyrrolidine-1-carbonyl)-biphenyl-3-yloxy]-hexyl}-phenoxy)-butyric acid (64 mg, 99%) as a white amorphous solid.

Provenance & Evidence