Ethanol → HCID 67339698, compound
Reaction equation
C(C[CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25]C2C=C(C3C=CC(F)=C(F)C=3)C=C(C(=O)N(C)C)C=2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])(O)=O.C(OC(=O)CCCOC1C=CC=C(CCCCCCO[C:66]2[CH:67]=[C:68]([C:81]3[CH:86]=[CH:85][CH:84]=[C:83]([F:87])[CH:82]=3)[CH:69]=[C:70]([C:72]([N:74]3[CH2:78][CH2:77][C:76]([F:80])([F:79])[CH2:75]3)=[O:73])[CH:71]=2)C=1CCC(OCC)=O)C.[OH-:96].[Na+].[CH3:98][CH2:99][OH:100]>>[C:99]([CH2:98][CH2:5][C:6]1[C:18]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][O:25][C:70]2([C:72]([N:74]3[CH2:78][CH2:77][C:76]([F:80])([F:79])[CH2:75]3)=[O:73])[CH:71]=[CH:66][CH:67]=[C:68]([C:81]3[CH:86]=[CH:85][CH:84]=[C:83]([F:87])[CH:82]=3)[CH2:69]2)=[CH:17][CH:16]=[CH:15][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])([OH:100])=[O:96]Participants
5
Procedure
The title compound was prepared by the same method as 4-{2-(2-carboxy-ethyl)-3-[6-(5-dimethylcarbamoyl-3′,4′-difluoro-biphenyl-3-yloxy)-hexyl]-phenoxy}-butyric acid starting from 4-[3-{6-[5-(3,3-difluoro-pyrrolidine-1-carbonyl)-3′-fluoro-biphenyl-3-yloxy]-hexyl}-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester (105 mg, 0.148 mmol) and 1.0 N aqueous NaOH (1.48 mL) in EtOH (5 mL) to afford 4-(2-(2-carboxy-ethyl)-3-{6-[3-(3,3-difluoro-pyrrolidine-1-carbonyl)-3′-fluoro-biphenyl-3-yloxy]-hexyl}-phenoxy)-butyric acid (94.6 mg, 98%) as a white amorphous solid.
Sources & evidence
- ORD record
- ord-b7ab25d264144dfd8919b28f9ec225a7
- Source dataset
- uspto-grants-2011_08
- Patent number
- US07989454B2
Reaction notes
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