(2,3-Dihydro-1-benzofuran-5-yl)boronic acid → HCID 67338531, compound

HRID 1670150Notes

Reaction equation

HRID 1670150 reaction equation
C([O:3][C:4](=[O:41])[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28](=[O:32])[N:29]([CH3:31])[CH3:30])[CH:25]=[C:24](Br)[CH:23]=2)[C:10]=1[CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])C.[O:42]1[C:46]2[CH:47]=[CH:48][C:49](B(O)O)=[CH:50][C:45]=2[CH2:44][CH2:43]1>>[C:36]([CH2:35][CH2:34][C:10]1[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[C:26]([C:28](=[O:32])[N:29]([CH3:30])[CH3:31])[CH:25]=[C:24]([C:49]3[CH:48]=[CH:47][C:46]4[O:42][CH2:43][CH2:44][C:45]=4[CH:50]=3)[CH:23]=2)=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([OH:41])=[O:3])([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 2773380(2,3-Dihydro-1-benzofuran-5-yl)boronic acidHCID 67338116HCID 67338116, compound

Product 1

HCID 67338531HCID 67338531, compound

Procedure

The title compound was prepared according to the general procedure described in Steps 3 and 4 of Method F starting from 4-[3-[6-(3-bromo-5-dimethylcarbamoyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy]-butyric acid ethyl ester and 2,3-dihydrobenzofuran-5-boronic acid. LC/MS indicated a purity of 93% as measured by UV 214 nM.

Sources & evidence

ORD record
ord-3a74afd73d5f4803a9e3d59adfba4c79
Source dataset
uspto-grants-2011_08
Patent number
US07989454B2

Reaction notes

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