HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 4-(3-Fluoro-4-pivalamidophenoxy)picolinamide | HCID 59853060 | — |
| Product | N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide | HCID 59852964 | 70% |
Reaction Steps
Prepared in a manner similar to that which is described in Step A of Example 91. 4-(3-Fluoro-4-pivalamidophenoxy)picolinamide (110 mg, 0.33 mmol) in acetonitrile (4 mL) was converted to N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 70% yield). MS (ESI+): m/z 304.21 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989477B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-bb157ce6227f4fd3b13263ed3e299953 |
| Source note | uspto-grants-2011_08 |