HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloropyridine-2-carboxamide → 4-(4-Amino-2,6-difluorophenoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloropyridine-2-carboxamide | HCID 303543 | — |
| Reactant | 4-Amino-2,6-difluorophenol | HCID 2778764 | — |
| Reactant | 1-(4-(2-Amino-3-(4-(2-amino-2-oxoethyl)phenyl)pyridin-4-yloxy)-3-fluorophenyl)-3-(2-(4-fluorophenyl)acetyl)urea trifluoroacetic acid salt | HCID 25195742 | — |
| Product | 4-(4-Amino-2,6-difluorophenoxy)picolinamide | HCID 59852853 | 29% |
Reaction Steps
4-Chloropicolinamide (0.47 g, 3.0 mmol) was converted to the title compound (0.23 g, 29%) in a manner similar to the preparation of Compound C of Example 112, except that 4-amino-2,6-difluorophenol (0.44 g, 3.0 mmol) was used instead of 4-amino-2,5-difluorophenol. 1H NMR (DMSO-d6) δ 8.60 (d, 1H, J=5.6 Hz), 8.22 (br s, 1H), 7.83 (br s, 1H), 7.45-7.46 (m, 1H), 7.30-7.32 (m, 1H), 6.43-6.49 (m, 2H), 5.94 (s, 2H); MS (ESI+) m/z 266 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989477B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-9d2e8c35f1c9462b89952dee76b83dcc |
| Source note | uspto-grants-2011_08 |