4-Fluoroaniline → 1-(4-Fluorophenyl)-2-oxo-3-pyrrolidinecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of 6,6-dimethyl-5,7-dioxaspiro[2.5]-octane-4,8-dione (Aldrich, 51 mg, 0.3 mmol) in DMF (0.5 mL) at room temperature was added 4-fluoroaniline (Aldrich, 33 mg, 0.3 mmol). The reaction mixture was heated at 90° C. for 2 h, cooled to room temperature, and used directly in the next step.

Provenance & Evidence