HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59852848, compound → HCID 59853029, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59852848 | HCID 59852848 | — |
| Reactant | N-(4-(6-(4-(Benzyloxy)phenylamino)pyrimidin-4-yloxy)-3-fluorophenyl)-N3-(4-fluorophenyl)malonamide | HCID 59853038 | — |
| Product | HCID 59853029 | HCID 59853029 | 18% |
Reaction Steps
Ethyl 3-(4-(2-aminopyridin-4-yloxy)-2,5-difluorophenylamino)-3-oxopropanoate (0.24 g, 0.68 mmol) was converted to the title compound (0.039 mg, 18%) in a manner similar to the preparation of Compound B of Example 116. HRMS (ESI+), Calcd.: 324.0796 (M+H)+. found: 324.0795 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989477B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cd4e6fcc291e4da5aff1f6a2c60258d4 |
| Source note | uspto-grants-2011_08 |