Erythritol → HCID 178481191, compound

Participants

Reaction Steps

A casting solution was prepared containing 4.0% CMC and 1.0% erythritol. A 10.0 mg aliquot of scopolamine HCl was dissolved into 50 g of the casting solution thereby yielding a scopolamine HCl concentration of 200 μg/g of the casting solution. A 1.2543 g amount of the casting solution containing the drug was equally divided between the three wells of the sample BP strip. PAM® was employed as a release agent. After 45 minutes in the IR drying tunnel the recovered weight was 105% of the theoretical NVS. The resulting films easily released from the casting well and were clear and flexible. Each film swatch averaged 22 mg and contained 8.4 μg of scopolamine HCl.

Provenance & Evidence