Hydrochloric Acid → (S)-3-Amino-1-methyl-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one hydrochloride

Participants

Reaction Steps

4.36 g of 7a (15.01 mmol) are taken up in a 250 ml round-bottomed flask and 110 ml of a solution of hydrochloric acid in dioxane (4M) are added. The mixture is stirred for 4 h at AT under argon. After the solvent has been evaporated off, the solid is disintegrated with 25 ml of isopropyl ether, and filter-dried over sintered glass. After drying, 3.1 g of amine 8a in hydrochloride form are obtained, which amine is used directly for the following step.

Provenance & Evidence