HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3S)-3-amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl [(3S)-1,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]carbamate | HCID 57617768 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3S)-3-amino-1,5-dimethyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one hydrochloride | HCID 67329118 | — |
Reaction Steps
206.8 mg of 17 (0.677 mmol) are taken up in a 25 mL round-bottomed flask and 5 mL of a solution of hydrochloric acid in dioxane (4M) are added. The medium is stirred overnight at RT under argon. A precipitate forms. After having evaporated the solvent under vacuum, 213 mg of expected product 18 (white solid) are obtained in hydrochloride form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994161B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-4d44323f47714f2493d49307a47d9fed |
| Source note | uspto-grants-2011_08 |