N-(tert-butoxycarbonyl)-O-(3-nitrobiphenyl-2-yl)-L-serine → O-(3-aminobiphenyl-2-yl)-N-(tert-butoxycarbonyl)-L-serine

Participants

Reaction Steps

In an autoclave containing 500 mg of 35 (1.243 mmol), 54 mg of Pd/C (10%) and 33 mL of EtOH, hydrogenation is performed at 2 bar for 10 h at 20° C. After filtration of the catalyst on celite, the solvent is evaporated and 284 mg of expected product 36 are obtained, which product is used directly for the next step.

Provenance & Evidence