HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3S)-3-amino-9-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl [(3S)-4-oxo-9-phenyl-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]carbamate | HCID 86628748 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (3S)-3-amino-9-phenyl-2,3-dihydro-1,5-benzoxazepin-4(5H)-one hydrochloride | HCID 67328839 | — |
Reaction Steps
3.4 mL of a solution of hydrochloric acid in dioxane (4M) are added to a 25 mL round-bottomed flask containing 160 mg of 37 (0.452 mmol). The mixture is stirred for 4 h at RT under argon. The dioxane is concentrated, and taken up in 15 mL of isopropyl ether. The solid formed is disintegrated. 113 mg of amine 38 (cream-coloured solid) are obtained after filtration in hydrochloride form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994161B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-83de2da5b1924fdfa043bc0e6ab760bf |
| Source note | uspto-grants-2011_08 |