N-(tert-butoxycarbonyl)-O-(2-nitrobiphenyl-3-yl)-L-serine → O-(2-aminobiphenyl-3-yl)-N-(tert-butoxycarbonyl)-L-serine

Participants

Reaction Steps

In an autoclave containing 280 mg of 41 (0.696 mmol), 30 mg of Pd/C (10%) and 18 mL of MeOH, hydrogenation is performed at 2 bar for 10 h at 20° C. After filtration of the catalyst on celite, the solvent is evaporated and 260 mg of expected product 42 are obtained, which product is used directly for the next step.

Provenance & Evidence