Water → (4R,4aS,7R,7aR)-4-[(1R)-1,2-dihydroxyethyl]-7-ethoxy-2,2-dimethyltetrahydro-6H-furo[3,2-d][1,3]dioxin-6-one

Participants

Reaction Steps

2.62 g of 48 (8.28 mmol) are introduced into a 100 mL three-necked flask containing 16 mL of water and 16 mL of acetic acid. The medium is stirred for 24 h at RT and then the reaction medium is concentrated under vacuum. The residues are disintegrated with 25 mL of isopropyl ether, filtered and dried under vacuum. 2.15 g of expected product 49 (white solid) are obtained.

Provenance & Evidence