反应详情

10 mg of palladium tetrakistriphenylphosphine are added to a solution of 13.2 g of allyl {2-(4-chlorophenyl)-1-[(2,2-diethoxyethyl)isopropylcarbamoyl]ethyl}carbamate, 18.9 g of dimethylbarbituric acid in 140 ml of methylene chloride under a protective argon gas atmosphere, and the reaction mixture is stirred for 12 h at room temperature. The reaction solution is concentrated under reduced pressure and purified by flash chromatography on silica gel (eluent methylene chloride, 1% Et3N, 0-10% methanol). The desired product is obtained with MW=356.90 (calculated monoisotopic); measured value (M−C2H6O+H)+: 311.10

1. concentrationThe reaction solution is concentrated under reduced pressure
2. custompurified by flash chromatography on silica gel (eluent methylene chloride, 1% Et3N, 0-10% methanol)