1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 10632446, compound

Participants

Reaction Steps

To crude (S)-(1-phenylethyl)-(2′,2′,2′-trifluoro-1-methylethylidene)-amine (1410 g, 4.54 mol theory) and washings with 20 g of toluene at room temperature, add DBU (1050 g, 6.897 mol) in portions to keep temperature below 60° C. Heat the reaction at 60° C. overnight (14 h) under nitrogen until the starting material rearranges to the desired intermediate (2460 g of solution). MS (ES+) m/z: 216.2 (M+H)−.

Provenance & Evidence