Sodium Carbonate → HCID 178433557, compound

Participants

Reaction Conditions

Reaction Steps

Carefully add chlorosulfonic acid (30 mL) to neat 2-methylimidazole (5 g, 60.9 mmol). Heat the mixture at 150° C. for 3 h and cool to room temperature. Add thionyl chloride (10 mL), heat at 100° C. for 3 h and cool to room temperature. Carefully pour the mixture into ice. Slowly add solid sodium carbonate to neutralize the solution. Filter the precipitate formed and wash with water. Dry the solid under high vacuum overnight at 45° C. to give the desired intermediate (4.38 g, 40%). MS (ES+) m/z: 181 (M+H)+.

Provenance & Evidence