反应详情

Add succinic acid (0.053 g, 0.453 mmol) to a mixture of 7-chloro-6-{4-[2-(cyclopropylmethyl-amino)-thiazol-4-yl]-phenylthiomethyl}-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.207 g, 0.452 mmol) in absolute ethanol (10 mL) at room temperature and stir for 1 h. Concentrate the reaction mixture in vacuo. Combine the residue with MTBE (5 mL) and concentrate three times to afford a pale yellow foam. Dry under high vacuum at room temperature overnight to obtain the title compound (0.259 g, 99%) as a pale yellow foam. MS (ES+) m/z: 456.0 (M+H)+.

1. concentrationConcentrate the reaction mixture in vacuo
2. concentrationconcentrate three times
3. customto afford a pale yellow foam
4. customDry under high vacuum at room temperature overnight