反应详情

Add succinic acid (0.073 g, 0.619 mmol) to a mixture of 7-chloro-6-{5-[2-(cyclopropylmethyl-amino)-thiazol-4-yl]-pyridin-2-ylthiomethyl}-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.282 g, 0.618 mmol) in methanol (5 mL) at room temperature. Concentrate the reaction mixture in vacuo. Combine the residue with MTBE (5 mL) and concentrate three times to afford a pale yellow foam. Dry under high vacuum at room temperature overnight to obtain the title compound (0.348 g, 98%) as a pale yellow foam. MS (ES+) m/z: 457.0 (M+H)+.

1. concentrationConcentrate the reaction mixture in vacuo
2. concentrationconcentrate three times
3. customto afford a pale yellow foam
4. customDry under high vacuum at room temperature overnight