Dimethylbarbituric acid → HCID 25234731, compound

Participants

Reaction Conditions

Reaction Steps

Prepared using General Procedure 5. The (S)-N-allyl-6-(3-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide (94 mg, 0.18 mmol), 1,3-dimethylbarbituric acid (166 mg, 1.06 mmol), and palladium-tetrakis(triphenylphosphine) (42 mg, 0.036 mmol) were combined in a flask and the flask placed under N2. Acetonitrile (1.2 mL) was then added and the suspension was heated to 60° C. After 1.5 hours the suspension was filtered and concentrated. The residue was purified by mass-trigger LC/MS (10%-99% CH3CN/H2O (0.05% TFA)) over 15 minutes to yield (S)-6-(3-(6-chloro-3,4-dihydroquinolin-1(2H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)pyridine-3-sulfonamide. LC/MS (10%-99% CH3CN/H2O (0.05% TFA)), m/z: M+1 obs=490.3, tR=1.81 min.

Provenance & Evidence