HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131729090, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (3S,4S)-4-(4-Bromo-2-nitro-phenylamino)-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester | HCID 67335296 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 131729090 | HCID 131729090 | 80% |
Reaction Steps
Add 4 M hydrogen chloride in dioxane (90 mL) slowly to a solution of (3S,4S)-4-(4-bromo-2-nitro-phenylamino)-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (0.035 mol, 14.6 g) in dry dichloromethane (50 mL) at room temperature and stir for 16 h. Filter the precipitate and dry under vacuum to obtain the title compound (9.84 g, 80%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994164B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-d8dc6c10e3a14072823fd7cb1fa5f6b2 |
| Source note | uspto-grants-2011_08 |