1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 178432702, compound

Participants

Reaction Steps

To a solution of Example 1 (30 mg, 0.082 mmol) in DCM was added DMAP (2 mg, 0.02 mmol), TEA (16 μL, 0.122 mmol), EDCI (20 mg, 0.11 mmol) and finally methanesulfonamide (11 mg, 0.11 mmol, CAS 3144-09-0). The solution was stirred at RT overnight. The crude was concentrated and purified by HPLC (acidic). Evaporation and co-evaporation with toluene gave title compound (22 mg, 60%).

Provenance & Evidence