p-Toluenesulfonyl azide → HCID 76698475, compound

HRID 1670664Notes

Reaction equation

HRID 1670664 reaction equation
[CH2:1]([O:3][C:4](=[O:11])[CH2:5][C:6](=[O:10])[CH:7]([F:9])[F:8])[CH3:2].S([N:22]=[N+:23]=[N-])(C1C=CC(C)=CC=1)(=O)=O>>[N+:22](=[C:5]([C:6](=[O:10])[CH:7]([F:9])[F:8])[C:4]([O:3][CH2:1][CH3:2])=[O:11])=[N-:23]

Participants

3

Reactant 2

HCID 13661p-Toluenesulfonyl azideHCID 67697Ethyl 4,4-difluoroacetoacetate

Product 1

HCID 76698475HCID 76698475, compound

Procedure

This compound was synthesised from 4,4-difluoro-3-oxo-butyric acid ethyl ester (CAS 352-24-9) and polymer-bound tosylazide using similar conditions as described in Intermediate 1-7. The crude was used directly in next step.

Sources & evidence

ORD record
ord-2efc995f480346a5aff091bc1b30aae9
Source dataset
uspto-grants-2011_08
Patent number
US07994179B2

Reaction notes

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