HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1670668Generated: October 27, 2026
N-methyl-2-pyrrolidone → 6-chloropyrazine-2-carboxamide
https://huagongshe.com/reaction/1670668
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | 6-Chloropyrazine-2-carboxylic acid | HCID 14500875 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-chloropyrazine-2-carboxamide | HCID 1282529 | 34% |
Reaction Steps
A solution of 6-chloro-pyrazine carboxylic acid (2.00 g, 12.62 mmol) in DMF (7 mL) was cooled to −40° C. NMP (2.77 mL, 25.23 mmol) and isobutyl chloroformate 3.27 mL, 25.23 mmol) were added. The temperature was allowed to increase to −20° C. during 20 min and then NH4OH was added. A precipitate was rapidly formed and after 15 min it was filtered off and washed with water. Crystallization from EtOH gave the title compound (670 mg, 34%) as light-brown needles.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07994179B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-33ab6d8102cd4e9ea026058c8acacab9 |
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| Source note | uspto-grants-2011_08 |
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