Ammonia → HCID 178501031, compound

Participants

Reaction Steps

Ethyl chloroformate (245 μl, 2.54 mmol) was added dropwise to a stirred solution of 6-{4-[trans-4-(methoxycarbonyl)cyclohexyl]phenyl}-5-methylpyrazine-2-carboxylic acid (Intermediate 65-1, 751 mg, 2.12 mmol) and N-methylmorpholine (350 μl, 3.18 mmol) in DCM (20 mL) at 0° C. Ammonia (5 mL of a 7M solution in MeOH) was added. The reaction mixture was allowed to warm up over 1 h then was concentrated and the residue was purified by chromatography eluting with 0-10% MeOH/DCM to give the title compound (226 mg, 30%) as a solid; 1H NMR δ 9.00 (1H, s), 8.08 (1H, s), 7.74 (1H, s), 7.70 (2H, d), 7.40 (2H, d), 3.63 (3H, s), 2.70-2.55 (1H, m), 2.67 (3H, s), 2.50-2.35 (1H, m), 2.10-1.98 (2H, m), 1.96-1.83 (2H, m), 1.65-1.43 (4H, m); MS 354.

Provenance & Evidence