Lithium hydroxide, monohydrate → HCID 178432794, compound

Participants

Reaction Steps

Lithium hydroxide monohydrate (42 mg, 1.00 mmol) was added to a stirred solution of methyl trans-4-{4-[6-(aminocarbonyl)-3-methylpyrazin-2-yl]phenyl}-cyclohexanecarboxylate (Example 65, 71 mg, 0.20 mmol) in MeOH (2 mL), THF (1 mL) and water (0.5 mL). After 16 h the reaction mixture was concentrated in vacuo and purified by reverse phase HPLC (150 mm×21 mm Phenomenex Column packed with Luna 10u C18 silica, eluting with 5-95% acetonitrile/water) to give the title compound as a yellow solid (6 mg, 9%); 1H NMR δ 9.01 (1H, s), 8.08 (1H, s), 7.73 (1H, s), 7.70 (2H, d), 7.40 (2H, d), 2.70-2.50 (1H, m), 2.65 (3H, s), 2.37-2.25 (1H, m), 2.10-2.00 (2H, m), 1.95-1.85 (2H, m), 1.65-1.40 (4H, m); MS 340.

Provenance & Evidence