Hydrogen Bromide → HCID 57767009, compound

Participants

Reaction Steps

A suspension of 9-methoxy-6-(4-nitrophenyl)-pyrimido[2′,1′:2,3]imidazo[4,5-c]-isoquinolin-5(6H)-one (17) (0.26 mmol, 0.100 g) in a concentrated aqueous HBr solution (5 ml) was refluxed overnight. The reaction mixture was evaporated under reduced pressure. The crude product was brought on a filter and washed with methanol, isopropanol and isopropylether successively to give the hydrobromide salt of 9-hydroxy-6-(4-nitrophenyl)-pyrimido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (97) (0.025 g, yield=8%, purity (LC)=90%).

Provenance & Evidence