反应详情

温度

180 °C

A mixture of compound 21 (1.0 equiv., 0.583 mmol, 0.228 g) and 2-amino-1-propanol (1.5 ml) was stirred for 50 min under microwave irradiation (microwave settings: temperature=180° C., maximum pressure=17 bar, maximum power=200 W). The reaction mixture was mixed with water (10 ml) and stirred at room temperature for 5 min. The resulting precipitate was filtered off and subsequently washed with water and tetrahydrofuran to afford 6-[6-[(2-hydroxy-1-methyl-ethyl)amino]-pyridin-3-yl]-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (I11) (0.150 g, yield=67%, purity (LC)=96%).

1. stirringstirred at room temperature for 5 min
2. filtrationThe resulting precipitate was filtered off
3. washsubsequently washed with water and tetrahydrofuran