Acetic Anhydride → HCID 24771267, compound

Participants

Reaction Steps

Acetic anhydride (1.5 equiv., 0.829 mmol, 0.084 g) was added to a cooled (0° C.) solution of compound 53 (1.0 equiv., 0.553 mmol, 0.200 g) and triethylamine (1.5 equiv., 0.829 mmol, 0.085 g) in dichloromethane (6 ml). The reaction mixture was stirred at room temperature for 20 h. The solvent was evaporated under reduced pressure, and the resulting residue purified by column chromatography (dichloromethane/methanol 9:1; Rf=0.3) affording N-[6-(6-chloro-pyridin-3-yl)-5,6-dihydro-5-oxo-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-9-yl]-acetamide (56) (0.105 g, yield=47%, purity (LC)=90%).

Provenance & Evidence