Dimethylformamide dimethyl acetal → HCID 24771702, compound

Participants

Reaction Conditions

Reaction Steps

N,N-Dimethylformamide dimethyl acetal (10.0 equiv., 1.935 mmol, 0.231 g) was added to a suspension of compound 53 (1.0 equiv., 0.193 mmol, 0.070 g) in DMF (3 ml). The reaction mixture was stirred overnight at 110° C. The solvent was evaporated under reduced pressure. Isopropyl ether was added and the mixture was brought on a filter and washed with isopropyl ether to give 6-(6-chloro-pyridin-3-yl)-9-[[(dimethylamino)-methylene]amino]-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one (84) (0.050 g, yield=62%, purity (LC)=77%).

Provenance & Evidence