Trifluoroacetic acid → HCID 59419628, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(6-chloropyridin-3-yl)-2,2-dimethyl-3-phenylpropanoic acid (28 mg, 0.10 mmol), potassium carbonate (8 mg), and hydrazine (0.5 mL) was stirred at 110° C. for 11 hr under argon and then concentrated. The residue was mixed with formic acid (1 mL). The mixture was stirred at 100° C. for 2 hr and 120° C. for 1 hr. Concentration and purification using reverse phase HPLC (YMC S5 20×100 mm, 10 min. run, solvent A: 10% MeOH: 90% H2O: 0.1% TFA, solvent B: 90% MeOH, 10% H2O, 0.1% TFA) gave 3-([1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2-dimethyl-3-phenylpropanoic acid (33 mg, 0.081 mmol, 81% yield) as a TFA salt. MS found: (M+H)+=296.25.

Provenance & Evidence