tert-Butyl piperazine-1-carboxylate → HCID 23149920, compound

Participants

Reaction Steps

By a similar operation as in Starting Material Synthetic Example 16, 4-[4-fluoro-3-(trifluoromethyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester was synthesized from 5-bromo-2-fluorobenzotrifluoride (Aldrich Co., 1.5 g) and 1-(tert-butoxycarbonyl)piperazine (1.38 g). These were dissolved in ethyl acetate, 4N hydrochloric acid-ethyl acetate was added, and the mixture was stirred at room temperature for 6 hr. The precipitated solid was collected by filtration and dried to give 1-[4-fluoro-3-(trifluoromethyl)phenyl]piperazine hydrochloride (1.31 g, yield 75%).

Provenance & Evidence