Diethylamine → HCID 23149973, compound

Participants

Reaction Steps

5-Bromo-2-chlorobenzylbromide (1.3 g) was dissolved in acetonitrile (30 ml). Diethylamine (334 mg) and potassium carbonate (2 g) were added thereto, and the mixture was heated under reflux for 1 hr. After completion of the reaction, the reaction mixture was filtrated, and the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (elution solvent: hexane-ethyl acetate (2:1-1:2)) to give a white solid. By a similar operation as in Starting Material Synthetic Example 45, 4-{4-chloro-3-[(diethylamino)methyl]phenyl}piperidin-4-ol (610 mg, yield 46%) was obtained from this white solid (1.24 g).

Provenance & Evidence