Water → HCID 11461905, compound

Participants

Reaction Conditions

Reaction Steps

1H-Indazole-3-carbonylazide (synthesized according to the method described in Tetrahedron, 32, 4, 1976, 493-497, 200 mg) was dissolved in dimethylformamide (4 ml), and the mixture was stirred with heating at 100° C. for 30 min. 1-(4-Fluorophenyl)piperazine (Aldrich Co., 211 mg) was dissolved in dimethylformamide (1 ml) and added thereto, and the mixture was stirred with heating at 100° C. for 1 hr. After allowing to cool, water was added to the reaction mixture and the precipitated solid was collected by filtration and dried. The solid was washed in a suspension state with methanol to give 4-(4-fluorophenyl)-1-piperazinecarboxylic acid (1H-indazol-3-yl)amide (64 mg, yield 18%).

Provenance & Evidence