HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 58926882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-(3,4-Dichlorophenyl)piperazine | HCID 93601 | — |
| Reactant | HCID 12262771 | HCID 12262771 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 58926882 | HCID 58926882 | 50.5% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Ethyl 1H-indazol-3-ylcarbamate (250 mg), 1-(3,4-dichlorophenyl)piperazine (KANTO CHEMICAL CO. INC., 310 mg) and DBU (200 μl) were dissolved in dimethyl sulfoxide (4 ml), and the mixture was stirred with heating at 100° C. for 1 hr. By the work-up following the method of Example 12, 4-(3,4-dichlorophenyl)-1-piperazinecarboxylic acid (1H-indazol-3-yl)amide (240 mg, yield 50%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994196B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-94268bef720d48578fe6cd5ce4f1a961 |
| Source note | uspto-grants-2011_08 |