Water → HCID 58926847, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 1H-indazol-3-ylcarbamate (1.2 g) and the compound (1.46 g) of Starting Material Synthetic Example 106 were dissolved in dimethylformamide (10 ml), DBU (2.3 ml) was added thereto, and the mixture was stirred with heating at 120° C. for 2 hr. After completion of the reaction, the reaction mixture was diluted with methanol (3 ml) and 1N hydrochloric acid and water were added to the mixture. The precipitated solid was collected by filtration and vacuum dried to give 4-(2,3-dimethylphenyl)-4-hydroxy-1-piperidinecarboxylic acid (1H-indazol-3-yl)amide (1.02 g, yield 47%).

Provenance & Evidence