関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2,4-Difluoro-5-iodobenzoic acid | HCID 11129795 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2,4-Difluoro-5-iodobenzoyl chloride | HCID 57733987 | — |
反応手順
To a solution of 11 (74.0 g, 260 mmol) in toluene (370 mL) was added thionyl chloride (95 mL, 1300 mmol) in DMF (2.5 mL, 26 mmol) and the mixture was heated to reflux for 4 h. The mixture was cooled to approximately 60° C. and filtered to remove insoluble material. The filtrate was concentrated under reduced pressure and residual thionyl chloride was co-evaporated with toluene (2×120 mL) to give crude 12 which was used without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07994194B2 |
|---|
| 出典データセット | uspto-grants-2011_08 |
|---|
| ORD ID | ord-c4d12b2e96734e9aa9427c510d143ef6 |
|---|
| 出典メモ | uspto-grants-2011_08 |
|---|
