反应详情

Heat to reflux a solution of 5-bromo-1,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87%) of the product as white crystals.

1. temperatureHeat
2. temperatureCool
3. customthe reaction to room temperature
4. concentrationconcentrate to an orange residue
5. customPurify the residue by silica gel chromatography
6. washeluting with hexanes